Dr. Lang Wu, PhD, is a tenure-track Assistant Professor in the Population Science in the Pacific Program of the University of Hawaii Cancer Center. He has been trained in multiple disciplines of genetic and molecular epidemiology, bioinformatics, and biostatistics. He joined the University of Hawaii at Manoa in 2019 and is very passionate about the research to identify novel genes and biomarkers to improve etiology understanding and risk assessment of prostate and pancreatic cancers across multi-ethnic populations. In this funded study (R01CA263494-01A1), together with Dr. Chong Wu and other collaborators, Dr. Wu will conduct a proteome-wide association study (PWAS) in prostate cancer to identify putative causal protein biomarkers for prostate cancer risk and aggressiveness across Africans and Europeans, functionally characterize top protein biomarkers for their roles in prostate cancer biology, and develop and validate ethnicspecific and pan-ethnic prediction models for prostate cancer risk and aggressiveness. This study will generate important knowledge regarding prostate cancer etiology and develop improved prostate cancer risk/aggressiveness prediction models across Africans and Europeans. The proposed new methods can also be applied to other complex diseases.